PUBLICATION BY DR. MATTHIAS MAGOOLA, CHEMIST
Abstract
MicroRNAs (miRNAs) play a crucial role in maintaining cellular homeostasis by binding to messenger RNAs (mRNAs) and fine-tuning gene expression across various biological pathways.
The 2024 Nobel Prize in Medicine and Physiology for the discovery of miRNAs was long overdue. This recognition is expected to ignite a surge in research focused on miRNAs, mirroring the historical impact of previous RNA-related breakthroughs that earned prestigious awards.
Although miRNA-based therapies have been explored for treating several complex diseases, their full potential in regulating gene expression and addressing hundreds of diseases is still unfolding. With advancements in drug discovery tools, we anticipate an accelerated development and approval of novel miRNA-based drugs.
To foster this progress, this paper provides insights into:
- The current state of miRNA science
- The logical frameworks supporting miRNA therapies
- Intellectual property considerations
- Therapeutic formulations
- The regulatory processes for miRNA-based drug development
By presenting this information, we aim to encourage researchers to develop new and innovative miRNA therapies, leveraging the guidance and discussion provided in this study.
